MicroRNA biomarkers

MicroRNA Biomarkers and Platelet Reactivity

Platelets play a key role in hemostasis, initiating and propagating thrombosis. Dysregulation and inappropriate activation of platelets underpin a wide range of important diseases, including stroke and myocardial infarction, whereas impairment of platelet function results in bleeding disorders. Platelets are anucleate and were previously considered to be simple cytoplasmic fragments of megakary...

microRNA biomarkers in cystic diseases

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by targeting the 3'-untranslated region of multiple target genes. Pathogenesis results from defects in several gene sets; therefore, disease progression could be prevented using miRNAs targeting multiple genes. Moreover, recent studies suggest that miRNAs reflect the stage of the specific disease, such as carcinogenesis....

Extracellular microRNA: a new source of biomarkers.

MicroRNAs (miRNAs) are a recently discovered class of small, non-coding RNAs that regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in many cellular processes, including differentiation, neoplastic transformation, and cell replication and regeneration. Because of these regulatory roles, it is not surprising that aberrant miRNA expression has been implicated ...

Microrna Biomarkers For Identification Of Chondrosarcoma

Circulating microRNA Biomarkers of Diabetic Retinopathy.

The incidence of diabetes is increasing globally, and in spite of modern treatments for glucose, blood pressure, and lipids, the vascular and neurologic complications of diabetes still occur at unacceptably high rates. The personal and economic burdens are enormous. Diabetes is a common cause for vision loss (diabetic retinopathy [DR]), renal impairment (nephropathy), peripheral and autonomic n...